Fig. 2: Screening of candidate genes in high-altitude adaptation of yak. | Nature Communications

Fig. 2: Screening of candidate genes in high-altitude adaptation of yak.

From: Long read genome assemblies complemented by single cell RNA-sequencing reveal genetic and cellular mechanisms underlying the adaptive evolution of yak

Fig. 2: Screening of candidate genes in high-altitude adaptation of yak.

a The number of DEGs in lung, heart, spleen, kidney, muscle, and liver between taurine cattle (n = 3 biologically independent samples) and yak (n = 4 biologically independent samples) with high-FST SVs. 5 cattle and 5 yak lung tissue transcriptome data were used for analysis. Different letters (a, b, c) denotes statistical significance at P < 0.05 (One-way ANOVA with Tukey’s test for multiple comparisons; F = 1722; P < 0.0001). The error bars respectively are 2049.17 ± 28.76, 278.17 ± 24.79, 247.17 ± 25.96, 236.83 ± 79.19, 198.83 ± 23.64 and 166.33 ± 27.20 in six tissues. b The venn diagrams of three gene lists. List1: Genelist annotated with high-FST SVs. List2: Genelist annotated with high-FST SVs located in exon and promoter. List3: Differentially expressed genes between domestic yak and taurine cattle in lungs. c The motif enrichment results of peak located in the promoter with high-FST SVs. The p values were calculated using Fisher’s exact test. d The sequence information of five special motifs. Source data are provided as a Source Data file.

Back to article page