Fig. 3: Hepatic deletion of Mettl3 in mice induces steatosis and apoptosis.

a Representative H&E staining photographs of liver sections from Control and Mettl3 cKO mice at indicated time points postnatally (10 experiments were repeated independently with similar results). Scale bar = 50 μm. b Representative BODIPY staining fluorescent photographs of frozen liver sections from Control and Mettl3 cKO mice at 2 weeks and 4 weeks after birth (6 experiments were repeated independently with similar results). Cell nuclei were counterstained with Hoechst 33342 (also hereafter in similar experiments). Scale bar = 20 μm. c Representative TUNEL staining fluorescent photographs for frozen liver sections from Control and Mettl3 cKO mice 4 weeks after birth (6 experiments were repeated independently with similar results). Scale bar = 20 μm. d Quantification of TUNEL⁺ cells/Hoechst 33342⁺ cells ratio in liver sections from Control and Mettl3 cKO mice at 2 weeks and 4 weeks after birth (n = 3 for each group). Data in d were shown as mean ± SEM with the indicated significance (**P < 0.01; two-tailed student’s t-test). Source data are provided as a Source Data file.