Fig. 5: PhIP-seq/VirScan paired maternal and cord SARS-CoV-2 Spike protein epitope binding. | Nature Communications

Fig. 5: PhIP-seq/VirScan paired maternal and cord SARS-CoV-2 Spike protein epitope binding.

From: Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy

Fig. 5

A Heatmap displaying results of significant enriched (p < 0.001) linear SARS-CoV-2 Spike protein epitope binding from 15 paired mother-infant dyads in maternal plasma at delivery and cord plasma by vaccine type and time since vaccine dose 1. Areas of high cumulative epitope binding designated by regions 1–4. B Cumulative fold enrichment of mothers and infants linear SARS-CoV-2 Spike protein epitope binding. Counts per 100,000 reads for all peptides were modeled against the distribution of rp100k in healthy control samples modeled as normally distributed. One-sided calculated p values were corrected for multiple hypothesis using the Benjamini–Hochberg method. Any peptide with a corrected p value of <0.001 was considered significantly enriched over the healthy background. NTD = N-terminal domain, RBD = receptor binding domain, S1 = Spike 1 subunit, S2 = Spike 2 subunit, TM = Transmembrane. Source data are provided as a source data file link.

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