Table 3 Cluster characteristics

From: Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease

 

Minimal

Limbic predominant

Limbic predominant +

Diffuse

Hippocampal sparing

Discovery

Validation

Discovery

Validation

Discovery

Validation

Discovery

Validation

Discovery

Validation

N1

189 (59.1%)

313 (54.8%)

93 (29.1%)

230 (40.3%)

23 (7.2%)

11 (1.9%)

5 (1.6%)

11 (1.9%)

10 (3.1%)

6 (1.1%)

Females1

90 (47.6%)

173 (55.3%)

45 (48.4%)

126 (54.8%)

14 (60.9%)

5 (45.5%)

3 (60%)

4 (36.4%)

4 (40%)

4 (66.7%)

Cohort ADNI1

119 (63%)

118 (37.7%)

61 (65.6%)

87 (37.8%)

17 (73.9%)

5 (45.5%)

4 (80%)

4 (36.4%)

6 (60%)

2 (33.3%)

Cohort J-ADNI1

60 (31.7%)

90 (28.8%)

21 (22.6%)

69 (30%)

6 (26.1%)

5 (45.5%)

1 (20%)

3 (27.3%)

2 (20%)

1 (16.7%)

Cohort AIBL1

10 (5.3%)

33 (10.5%)

11 (11.8%)

30 (13%)

–

–

–

2 (18.15%)

2 (20%)

2 (33.3%)

Cohort AddNeuroMed1

–

72 (23%)

–

44 (19.2%)

–

1 (9%)

–

2 (18.15%)

–

1 (16.7%)

Age2

75.5 (7.6)

76.5 (6.7)

75.4 (8)

76.3 (6.7)

74.5 (7.3)

75.1 (7.9)

71.9 (11.6)

73.3 (5)

62.7 (7.9)

62.6 (7.3)

AD onset age2

73 (7.4)

74 (7.4)

73.1 (7.6)

75 (7.3)

73 (7.4)

72 (7.4)

66 (7.4)

73 (4.4)

61 (8.1)

60.9 (6.5)

Education class3

3.08 (0.93)

2.6 (1.13)

3.04 (1)

2.59 (1.08)

3 (0.9)

2.73 (1.01)

3.6 (0.55)

2.82 (1.08)

3.5 (0.85)

3 (1.26)

APOE e21,5

6 (3%)

17 (6%)

3 (3%)

13 (6%)

1 (4%)

1 (10%)

1 (20%)

1 (9%)

1 (10%)

1 (20%)

APOE e3e31,5

45 (24%)

99 (33%)

29 (31%)

77 (34%)

7 (30%)

1 (10%)

1 (20%)

5 (45.5%)

5 (50%)

0

APOE e41,5

142 (75%)

183 (60%)

62 (67%)

139 (62%)

16 (70%)

8 (80%)

3 (60%)

5 (45.5%)

4 (40%)

4 (80%)

ANART4

16.74 (0.42)

16.13 (0.58)

12.08a (1.07)

16.85 (2.2)

12.57a (1.8)

MMSE total5

23.11c (−0.42)

22.51a (−0.5)

24.95 (−1.99b)

21.83 (−0.5)

21.78 (−1.59b)

CDR3

0.72 (0.27)

0.86 (0.40)

0.75 (0.25)

0.89 (0.45)

0.76 (0.26)

0.75 (0.27)

0.67 (0.29)

1 (0.61)

0.71 (0.27)

0.88 (0.25)

CDR SOB3

4.02 (1.55)

4.34 (2.11)

4.28 (1.48)

4.40 (1.95)

4.45 (1.73)

4.64 (0.80)

3.83 (3.01)

4.93 (2.22)

4.29 (0.99)

4.67 (1.15)

GDS5

2.06 (0.02)

2.13 (−0.01)

2.19 (0.09)

0.84 (0.11)

1.96 (−0–01)

Alzheimer’s disease assessment scale

Word recall5

5.96 (0.09)

6.35a (0.04)

5.5 (0.55b)

7.01 (−0.03)

6.43 (0.36)

Following commands5

0.61 (0.01)

0.77 (0)

0.5 (0.11)

1.39 (−0.1)

1.7a (0.04)

Constructional praxis5

0.71 (0.01)

0.92 (−0.01)

0.7 (0.1)

0.89 (−0.08)

1.9a (0.01)

Naming objects and fingers5

0.39 (0.01)

0.51 (0.01)

0.28 (0.14)

0.51 (0)

1.13 (−0.23)

Ideational praxis5

0.49 (0.01)

0.61 (0.01)

0.41 (0.07)

0.6 (−0.05)

1.5 (0.01)

Orientation5

2.24 (0.17)

2.71 (0.08)

2.02 (0.75b)

2.39 (0.17)

2.4 (0.35)

Word recognition5

5.96 (0.13)

5.89 (0.1)

4.92 (0.5)

6.08 (0.01)

3.16 (0.98)

Recall instructions5

0.27c (0.05)

0.51 (0.03)

0.1 (0.06)

0.27 (0.04)

0.23 (0.19)

Spoken language5

0.31 (0.02)

0.44 (0.03)

0.15 (0.12)

0.52 (−0.02)

0.8 (−0.02)

Word finding difficulty5

0.63 (0.03)

0.87 (0.02)

0.29 (0.2)

0.43 (0.05)

1.61 (−0.17)

Comprehension of spoken language5

0.3 (0.02)

0.49 (0.01)

0.22 (0.09)

0.33 (−0.02)

0.54 (0)

  1. Notes: 1n (%); 2median (median absolute distance); 3mean (sd); 4estimated value at the AD onset (estimation standard error); 5estimated value at the AD onset (estimated annual change); 5the percentage denominator refers to the sum of the non-missing APOE records; education years are categorized in 4 classes (1  = <0–8 years; 2 = 9–13 years; 3 = 13–15 years, 4 > 15 years). Corrections for multiple comparisons were assessed with the Holms–Sidak method.
  2. ANART American National Adult Reading Test, MMSE Mini-Mental State Examination, CDR Clinical Dementia Rating, CDR SOB CDR sum of boxes, GDS Geriatric Depression Scale.
  3. aBaseline differences between cluster 1 and other clusters.
  4. bLongitudinal differences between cluster 1 and other clusters.
  5. cBaseline or longitudinal differences between discovery and validation dataset.
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