Table 3 Most significant 30 genes associated with ascending and descending aortic distensibility (gene-based analysis using MAGMA v1.08 as implemented in FUMA v1.3.6)
AA distensibility | DA distensibility | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
CHR | START | STOP | ZSTAT | P (adj) | SYMBOL | CHR | START | STOP | ZSTAT | P (adj) | SYMBOL |
1 | 52870236 | 52886511 | 5.01 | 2.68E-07 | PRPF38A | 2 | 20883788 | 21022882 | 5.6592 | 7.61E-09 | C2orf43 |
1 | 52873954 | 53019159 | 4.65 | 1.67E-06 | ZCCHC11 | 3 | 186935942 | 187009810 | 6.3839 | 8.63E-11 | MASP1 |
1 | 53068044 | 53074723 | 4.96 | 3.60E-07 | GPX7 | 5 | 95726119 | 95769847 | 4.0163 | 2.96E-05 | PCSK1 |
3 | 37027357 | 37034795 | 4.52 | 3.14E-06 | EPM2AIP1 | 7 | 73442119 | 73484237 | 4.4229 | 4.87E-06 | ELN |
3 | 123798870 | 124445172 | 4.85 | 6.25E-07 | KALRN | 8 | 75512010 | 75735548 | 4.0596 | 2.46E-05 | RP11-758M4.1 |
4 | 146678779 | 146859787 | 4.60 | 2.14E-06 | ZNF827 | 8 | 75736772 | 75767264 | 4.3374 | 7.21E-06 | PI15 |
5 | 81575281 | 81682796 | 4.68 | 1.40E-06 | ATP6AP1L | 8 | 92114060 | 92231464 | 5.0794 | 1.89E-07 | LRRC69 |
5 | 95726119 | 95769847 | 6.11 | 5.00E-10 | PCSK1 | 8 | 122624356 | 122653630 | 4.6601 | 1.58E-06 | HAS2 |
5 | 122424816 | 122529960 | 5.10 | 1.69E-07 | PRDM6 | 9 | 116638562 | 116818871 | 4.6059 | 2.05E-06 | ZNF618 |
6 | 12290596 | 12297427 | 4.72 | 1.18E-06 | EDN1 | 10 | 95753746 | 96092580 | 7.3635 | 8.96E-14 | PLCE1 |
7 | 73442119 | 73484237 | 7.11 | 5.85E-13 | ELN | 10 | 96162261 | 96295687 | 5.8888 | 1.95E-09 | TBC1D12 |
8 | 38585704 | 38710546 | 4.58 | 2.38E-06 | TACC1 | 10 | 96305547 | 96373662 | 5.2578 | 7.29E-08 | HELLS |
8 | 75512010 | 75735548 | 5.26 | 7.03E-08 | RP11-758M4.1 | 11 | 61535973 | 61560274 | 4.2122 | 1.26E-05 | TMEM258 |
8 | 75736772 | 75767264 | 6.13 | 4.27E-10 | PI15 | 12 | 33527173 | 33592754 | 4.8085 | 7.60E-07 | SYT10 |
8 | 122624356 | 122653630 | 6.11 | 5.00E-10 | HAS2 | 12 | 38710380 | 38717784 | 4.4827 | 3.69E-06 | ALG10B |
10 | 95753746 | 96092580 | 5.22 | 9.07E-08 | PLCE1 | 12 | 57489191 | 57525922 | 4.3707 | 6.19E-06 | STAT6 |
11 | 69924408 | 70035634 | 5.15 | 1.34E-07 | ANO1 | 12 | 94071151 | 94288616 | 4.6778 | 1.45E-06 | CRADD |
12 | 21950335 | 22094336 | 5.58 | 1.19E-08 | ABCC9 | 14 | 92335756 | 92414331 | 5.5917 | 1.12E-08 | FBLN5 |
12 | 57489191 | 57525922 | 5.26 | 7.24E-08 | STAT6 | 15 | 32737307 | 32747835 | 4.6319 | 1.81E-06 | GOLGA8O |
15 | 71389291 | 72075722 | 5.27 | 7.01E-08 | THSD4 | 15 | 74218330 | 74244478 | 4.3266 | 7.57E-06 | LOXL1 |
15 | 78916461 | 79020096 | 4.96 | 3.47E-07 | CHRNB4 | 15 | 91426925 | 91439006 | 4.7615 | 9.61E-07 | FES |
16 | 75327596 | 75467383 | 4.83 | 6.82E-07 | CFDP1 | 16 | 75327596 | 75467383 | 6.6103 | 1.92E-11 | CFDP1 |
16 | 75446582 | 75498604 | 4.59 | 2.19E-06 | RP11-77K12.1 | 16 | 75446582 | 75498604 | 6.2293 | 2.34E-10 | RP11-77K12.1 |
16 | 88941266 | 89043612 | 5.06 | 2.12E-07 | CBFA2T3 | 16 | 75476952 | 75499395 | 6.0227 | 8.58E-10 | TMEM170A |
16 | 89006197 | 89017932 | 5.07 | 1.98E-07 | RP11−830F9.6 | 16 | 75510949 | 75529282 | 4.8918 | 4.99E-07 | CHST6 |
17 | 1957448 | 1962981 | 5.39 | 3.45E-08 | HIC1 | 16 | 89724210 | 89737680 | 4.1797 | 1.46E-05 | SPATA33 |
17 | 1963133 | 2207065 | 8.24 | 8.86E-17 | SMG6 | 17 | 1963133 | 2207065 | 6.0905 | 5.63E-10 | SMG6 |
17 | 2206677 | 2228554 | 7.68 | 7.83E-15 | SRR | 17 | 2206677 | 2228554 | 5.3263 | 5.01E-08 | SRR |
17 | 2225797 | 2240801 | 5.33 | 4.80E-08 | TSR1 | 19 | 39138289 | 39222223 | 5.3381 | 4.70E-08 | ACTN4 |
20 | 47240790 | 47444420 | 4.61 | 2.04E-06 | PREX1 | 19 | 39220827 | 39260544 | 4.6378 | 1.76E-06 | CAPN12 |
