Fig. 3: Most individual recovering patients follow the same WBC-PLT recovery shape, independent of inflammatory stimulus. | Nature Communications

Fig. 3: Most individual recovering patients follow the same WBC-PLT recovery shape, independent of inflammatory stimulus.

From: Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations

Fig. 3

a Across all 12 cohorts, individual patient WBC recovery dynamics are well-approximated by the model with median adjusted R2 = 0.85, as are individual PLT recovery dynamics (b) with a median adjusted R2 of 0.95 following a variable delay. c WBC-PLT dynamics for representative patients follow the model. Representative patients are those with each inflammatory condition whose WBC-PLT data had model fits closest to the cohort median adjusted R2. These patients exhibit exponential WBC decay and delayed linear PLT increase during recovery despite significant differences in gender and age (bottom left of each panel), inflammatory stimulus, CBC frequency, and magnitude of WBC and PLT count changes. See Supplementary Figs. 9–10 for additional representative WBC-PLT dynamics for patients whose raw WBC-PLT data had model fits near the 25th and 75th percentiles of the cohort adjusted R2 distributions. Thin black lines in panels (a), (b) are shown for 500 patients randomly selected from the adjusted R2 distributions. Source data are provided as a Source data file. WBC: white blood cell count, PLT: platelet count, M: male, F: female.

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