Table 3 Adjusted mean differences from fitting an ANCOVA model (contrasts between groups)

From: Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV

 

Unadjusted and adjusted mean difference at T1 (log2 scale)

Unadjusted Mean (95% CI)

p-value

Adjusted* mean (95% CI)

p-value

 

RBD-binding IgG

HCDR

0

 

0

 

ICDR

0.66 (0.09, 1.24)

0.025

0.50 (−0.08, 1.08)

0.093

PCDR

1.09 (0.38, 1.80)

0.003

0.05 (−0.84, 0.94)

0.910

 

nAb titres

HCDR

0

 

0

 

ICDR

0.51 (−0.16, 1.17)

0.136

0.27 (−0.47, 1.01)

0.478

PCDR

0.13 (−0.69, 0.95)

0.755

−0.70 (−1.84, 0.45)

0.234

 

IFN-γ

HCDR

0

 

0

 

ICDR

−0.43 (−1.36, 0.49)

0.358

−0.03 (−1.15, 1.10)

0.962

PCDR

−0.43 (−1.59, 0.73)

0.470

−0.43 (−2.18, 1.31)

0.628

  1. *adjusted for age, time from HIV diagnosis, CD4 count nadir,VL < = 50 copies/mL at T0, days from the date of 2nd dose, vaccine sequence,and concomitant cancer.
  2. &from the adjusted model; Global Wald test, 2-sided no adjustment for multiple comparisons.