Fig. 9: 4-methoxyacetophenone is a high affinity ligand for Olfr1377.
a Spectra of Olfr1377 and Olfr881 glomerular ΔF/F responses (sorted by Olfr1377 response magnitude) to a subset of ligands detected within a larger odorant panel. Odorants presented at an estimated concentration on the order of 100 nM, with the exception of 4-methoxyacetophenone (~3.5 nM for Olfr881; ~3.5 × 10−3 nM for Olfr1377). Source data provided as a Source Data file. b Chemical structures of a subset of ligands identified by functional imaging for Olfr1377 (solid box) and Olfr881 (dashed box), including multiple overlapping cyclic ketone ligands. c In vivo concentration-response function of the Olfr1377 glomerulus to 4-methoxyacetophenone, n = 3 trials. Point and error bars represent mean and standard deviation, respectively. Source data provided as a Source Data file. d In vitro concentration-response function of the Olfr1377 receptor to an array of cyclic ketone odorants, n = 3 biologically independent replicates. Point and error bars represent mean and standard deviation, respectively. Source data provided as a Source Data file.
