Fig. 1: Schematic representation of synthetic nano-chaperones for peptide (SNCP) based on porous nanoparticles.
From: Multifunctional synthetic nano-chaperone for peptide folding and intracellular delivery
After encapsulation of p53pep, structural stabilization of p53pep is induced from a random-coil structure to an α-helical structure. In situ click reaction for peptide stapling then proceeds while p53pep is loaded inside SNCP to make the α-helical structure of p53pep irreversible. Finally, direct cellular delivery of st-p53pep using SNCP results in p53 mediated apoptosis of cancer cells.
