Table 3 Enrichment patterns of the Allen brain expression candidate gene sets

Components	Gene sets	P_(95%)	P_(75%)	EXP#genes	OBS#genes	P_(FDR-BH)
Common	MFG	0.11	3.0e-3	241	275	1.80e-2
	SCG	0.29	0.09	239	254	0.18
	LOC	0.23	0.26	242	249	0.31
	BG	0.49	0.08	240	256	0.18
Updating-specific	MFG	0.40	0.29	241	247	0.32
	SCG	0.55	0.19	239	249	0.27
	LOC	0.46	0.19	241	251	0.27
	BG	0.63	0.53	240	238	0.53
Shifting-specific	MFG	0.27	0.02	143	164	0.08
	SCG	0.22	2.3e-3	139	166	1.8e-2
	LOC	0.50	0.06	149	165	0.18
	BG	0.96	0.20	139	147	0.27

MFG = the set of genes that showed enhanced expression in the middle frontal gyrus; SCG = the set of genes that showed enhanced expression in the paracingulate (subcallosal cingulate) gyrus; LOC = the set of genes that showed enhanced expression in the occipital gyrus, superior division; BG = the set of genes that showed enhanced expression in the basal ganglia. P_(95%): nominal gene-set enrichment P value for a candidate gene set (95% cutoff); P_(75%): nominal gene-set enrichment P value for a candidate gene set (75% cutoff); EXP#genes (75%): expected number of genes that were above 75% cutoff; OBS#genes (75%): observed number of genes that were above 75% cutoff. Correction for multiple comparisons was performed with the FDR-BH. One-sided test.

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