Fig. 1: Time course of vaccine-induced serum and mucosal anti-SARS-CoV-2 antibody titers in adult participants with or without previous SARS-CoV-2 infection.
From: SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
Anti-SARS-CoV-2 spike IgG titers in serum (a, b), anti-SARS-CoV-2 spike IgG titers in saliva (c, d), and anti-SARS-CoV-2 spike SIgA titers in saliva (e, f) collected from 18 individuals with previous SARS-CoV-2 infection (seropositive) and 11 individuals without previous SARS-CoV-2 infection (seronegative) prior to and after vaccination. 6–13 different timepoints were assessed per individual. X-axis values represent days post-first vaccination and Y-axis values represent antibody titers calculated as area under the curve (AUC). Syringe symbols point to the approximate time when the first and second vaccine dose were administered (28 days for Moderna mRNA-1273 vaccine and 21 days for the Pfizer-BioNTech BNT162b2 vaccine). Dotted lines are cut-off values (mean+3 SD of the AUC of samples from seronegative individuals before vaccination). Different colors represent different individuals. This data is also presented on a logarithmic scale in Supplementary Fig. 1. Source data are provided as a Source Data file.
