Table 1 Anion binding and transmembrane anion transport properties of compound 1, along with literature values of anion hydration free energies and anion binding properties of compound 2 and PC vesicles

From: Measuring anion binding at biomembrane interfaces

Anion

ΔGhydr (kJ mol–1)a

Association constant Ka (M–1)

Transport rate by 1/anions s–1 carrier–1 f

In DMSO-d6/0.5% H2O

In C12E8 micelles

In POPC vesicles

PC vesicles

1

2b

1

1

SO42–

–975

(7.4 ± 1.1)×109

>105

54,000 ± 3000

370 ± 10c

ND

0.042 ± 0.006

H2PO4

–473

>105

46,000

140 ± 20

<1

ND

0.031 ± 0.010

Cl

–344

2000 ± 100

670

19 ± 1c

<1

0.2d

0.082 ± 0.016

Br

–318

200 ± 10

70

29 ± 1c

2.6 ± 0.6c

2d

0.097 ± 0.018

NO3

–286

340 ± 10

10

210 ± 10c

24 ± 4c

2.8d

2.1 ± 0.1

I

–280

6.1 ± 0.6

3

200 ± 10c

24 ± 2c

32e

2.0 ± 0.4

ClO4

–229

<1

ND

32 ± 1c

45 ± 9c

115e

0.83 ± 0.10

  1. Errors represent SD from at least two experiments.
  2. ND not determined.
  3. aGibbs energies of hydration at 25 °C, compiled by Marcus25.
  4. bReported by Jurček et al.20.
  5. cIonic strength fixed at 0.2 M.
  6. dReported by Tatulian34, using egg PC vesicles.
  7. eReported by Rydall and Macdonald33, using POPC vesicles.
  8. fDetermined at an anion concentration of 20 mM.