Table 1 Anion binding and transmembrane anion transport properties of compound 1, along with literature values of anion hydration free energies and anion binding properties of compound 2 and PC vesicles
Anion | ΔGhydr (kJ mol–1)a | Association constant Ka (M–1) | Transport rate by 1/anions s–1 carrier–1 f | ||||
|---|---|---|---|---|---|---|---|
In DMSO-d6/0.5% H2O | In C12E8 micelles | In POPC vesicles | PC vesicles | ||||
1 | 2b | 1 | 1 | ||||
SO42– | –975 | (7.4 ± 1.1)×109 | >105 | 54,000 ± 3000 | 370 ± 10c | ND | 0.042 ± 0.006 |
H2PO4– | –473 | >105 | 46,000 | 140 ± 20 | <1 | ND | 0.031 ± 0.010 |
Cl– | –344 | 2000 ± 100 | 670 | 19 ± 1c | <1 | 0.2d | 0.082 ± 0.016 |
Br– | –318 | 200 ± 10 | 70 | 29 ± 1c | 2.6 ± 0.6c | 2d | 0.097 ± 0.018 |
NO3– | –286 | 340 ± 10 | 10 | 210 ± 10c | 24 ± 4c | 2.8d | 2.1 ± 0.1 |
I– | –280 | 6.1 ± 0.6 | 3 | 200 ± 10c | 24 ± 2c | 32e | 2.0 ± 0.4 |
ClO4– | –229 | <1 | ND | 32 ± 1c | 45 ± 9c | 115e | 0.83 ± 0.10 |