Fig. 4: MPS-PVP activates co-stimulatory pathways in RAW264.7 macrophages. | Nature Communications

Fig. 4: MPS-PVP activates co-stimulatory pathways in RAW264.7 macrophages.

From: Inorganic nanosheets facilitate humoral immunity against medical implant infections by modulating immune co-stimulatory pathways

Fig. 4: MPS-PVP activates co-stimulatory pathways in RAW264.7 macrophages.

a Volcano plots showing the expression levels of genes in different groups. b KEGG enrichment analysis reveals top 20 statistically significant (Q values <0.05) biological processes regulated by MPS-PVP. c Gene set enrichment analysis (GSEA) of representative immune signaling pathways in macrophages after MPS-PVP treatment. The ticks below the line represent the rank of each gene. NES, normalized enrichment score. d Heatmap showing DEGs after MPS-PVP treatment; yellow, upregulation; blue, downregulation; |log2 fold change| ≥ 1, Q values < 0.05. Key DEGs are marked on the right. e Gene–gene interaction network for genes associated with cell adhesion molecules in macrophages. The network nodes and the lines correspond to each gene and gene-gene interactions, respectively.

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