Fig. 3: The drug response prediction performance comparison among five methods based on the simulated data with completely separate prognostic and predictive SNPs and heritability fixed at 0.3.
From: Pharmacogenomics polygenic risk score for drug response prediction using PRS-PGx methods
The training sample size for PGx PRS approaches was fixed to be 3000. Numbers of the causal variants for P(causal) = 0.001, 0.01, and 0.1 are 5, 50, and 500, respectively. The performance was assessed in terms of a prediction accuracy R2 of SPGx in two arms, b predictive p-value for the two-sided Spred × T interaction test. Data are presented as mean values +/− standard deviations (error bars) with 10,000 replications, where results were calculated from the testing sets.
