Fig. 1: Rotations about single bonds and conformational enantiodiscrimination.
From: Conformational enantiodiscrimination for asymmetric construction of atropisomers
a C–C bond rotation in ethane. b Restricted rotation about the C–C single bonds in atropisomers. c Rotation about the C–C single bond locked in BINAP-metal complexes and BINOL-based phosphoric acids. d Design of a chiral catalytic system for conformational enantiodiscrimination enabling asymmetric construction of atropisomers with opposite absolute configurations. BINOL, 1,1′-bi-2-naphthol; BINAM, 1,1′-binaphthyl-2,2′-diamine; NOBIN, 2-amino-2′-hydroxy-1,1′-binaphthyl; BINAP, 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl; Ph, phenyl; CPA, chiral phosphoric acids.
