Fig. 2: Conformational enantiodiscrimination for the asymmetric cross-coupling of azonaphthalenes with 2-naphthylamines.
From: Conformational enantiodiscrimination for asymmetric construction of atropisomers
a Shield screening (48 h). b Influence of the hydroxy group (48 h). c Substrate scope (60 h). Reaction conditions: 1 (0.10 mmol), 2 (0.12 mmol), 1,2-dichlorobenzene (2.0 mL), under air, 30 °C unless noted otherwise (3n: 40 °C). All yields are isolated. Enantiomeric ratios (e.r.) were determined via HPLC analysis and reported as (R:S). Me, methyl; nPr, n-propyl; Bn, benzyl; Ph, phenyl. The absolute configuration of all the products with blue thick bonds is R.
