Fig. 4: Apical dental follicle cells largely contribute to the periodontal tissue in the furcation region of the mouse molar. | Nature Communications

Fig. 4: Apical dental follicle cells largely contribute to the periodontal tissue in the furcation region of the mouse molar.

From: Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis

Fig. 4: Apical dental follicle cells largely contribute to the periodontal tissue in the furcation region of the mouse molar.The alternative text for this image may have been generated using AI.

a UMAP plot of cellular domains in the mouse molar at P3.5. b, c Heatmap and Dotplot of signature genes of dental mesenchymal cell populations in the mouse molar. d–f Feature plot and RNAscope staining of lateral follicle markers in the mouse molar at P3.5 (n = 3). g Schematic drawing of the lateral follicle domain in the mouse molar at P3.5. h–j Feature plot and RNAscope staining of apical follicle markers in the mouse molar at P3.5 (n = 3). k Schematic drawing of the apical follicle domain in the mouse molar at P3.5. l–o Feature plot of Slc1a3 and lineage tracing analysis of Slc1a3+ cells in the mouse molar from P3.5 to P21.5 (n = 3). p UMAP plot of cellular domains in the mouse molar at P3.5 with annotation. q Schematic drawing of the cellular domains in the mouse molar at P3.5. Injection protocol is illustrated underneath the figures. Black dotted lines outline the cellular domains in the Feature plots. The white box in n is magnified in o. White dotted lines in o outline the PDL in the mouse molar. White arrows point to the positive signals. Yellow and green arrows in o point to the positive signals in PDL and alveolar bone in the root furcation region, respectively. Scale bars, 100 μm.

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