Fig. 9: Schematic representation of cell fate decisions in the dental mesenchyme during mouse molar formation.

a Landscape of cellular domain establishment and lineage development in the dental mesenchyme during mouse molar morphogenesis. b Apical follicle largely gives rise to periodontal tissue in the furcation region of the mouse molar, which is partially regulated by Foxp4. c Igf1-Igf1r signaling mediated cell-cell interaction is indispensable for PDL development.