Fig. 2: Heterologous vaccination induces neutralizing antibodies.

Heterologous ChAd/BNT/BNT or ChAd/ChAd/BNT vaccination induces neutralizing antibodies against (a), Wuhan and B.1.1.529 (Omicron) as well as b, B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (B.1.1.28.1; Gamma), and B.1.617.2 (Delta) SARS-CoV-2-S variants measured using the sVNT. For better visualization of identical titer values, data were randomly and proportionally adjusted closely around the precise titer results. The dotted line represents the lower limit of detection. a, b. Mixed effect analysis followed by Sidak’s multiple comparison test (within groups) and unpaired two-sided t test with Welch’s correction (between groups). The symbols depicted in grey have been published before15,19. Source data are provided as a Source Data file.