Fig. 2: Details of interface between DLC1 and p120RasGAP.
From: SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP
a Residue interactions adapted from PDBSum86 and PISA server44. Blue line indicates hydrogen bond, red line indicates salt bridge. The width of the black dashed lines is proportional to the number of non-bonded atomic contacts as calculated in PDBSum86. SH3 domain in purple and RhoGAP domain in teal. Residues mutated in this study are labeled in bold. b RT loop binding site. Insets show details of the interactions. Details of the interaction showing the SH3 domain contacts made by the n-Src loop (c) and β2-β3-β4 strands with αG (d).
