Table 4 Symptom outcomes by bamlanivimab dose cohort and treatment arm

From: Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19

 

7000 mg dose cohort

700 mg dose cohort

 

Bamlanivimab (N = 48)

Placebo (N = 46)

p-value

Bamlanivimab (N = 111)

Placebo (N = 112)

p-value

Time to symptom improvement from study entry (primary symptom outcome), median (IQR), days

21.0 (7.0, 28.0)

18.5 (7.0, 28.0)

0.97a

24.0 (14.0, 28.0)

20.5 (9.0, 28.0)

0.08a

Proportion of participants with at least 1 symptom reported as more severe than at study entry in study diary, n (%)

42 (87.5)

40 (87.0)

0.94b

102 (91.9)

105 (93.8)

0.59b

Symptom severity ranking (AUC of total symptom score days 0–28), median (IQR)

1.38 (0.93, 3.09)

1.88 (1.09, 3.05)

0.14a

2.34 (1.30, 3.93)

2.13 (1.06, 4.08)

0.65a

  1. IQR interquartile range, atwo-sided Wilcoxon test, btwo-sided Wald chi-square test.