Fig. 6: Model illustrating the role of KLF in regulating the endothelial enhancer landscape under LSS. | Nature Communications

Fig. 6: Model illustrating the role of KLF in regulating the endothelial enhancer landscape under LSS.

From: KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress

Fig. 6: Model illustrating the role of KLF in regulating the endothelial enhancer landscape under LSS.The alternative text for this image may have been generated using AI.

Laminar shear stress induces KLF, which interacts with the SWI-SNF chromatin remodeling complex to increase chromatin accessibility at gene regulatory regions and promote enhancer-promoter looping to LSS-responsive genes to increase gene expression.

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