Fig. 6: Model illustrating the role of KLF in regulating the endothelial enhancer landscape under LSS. | Nature Communications

Fig. 6: Model illustrating the role of KLF in regulating the endothelial enhancer landscape under LSS.

From: KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress

Fig. 6

Laminar shear stress induces KLF, which interacts with the SWI-SNF chromatin remodeling complex to increase chromatin accessibility at gene regulatory regions and promote enhancer-promoter looping to LSS-responsive genes to increase gene expression.

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