Fig. 3: Time-dependent changes in expression of a common subset of IFN regulators displaying on/fast-off kinetics distinguish ICB responders from non-responders. | Nature Communications

Fig. 3: Time-dependent changes in expression of a common subset of IFN regulators displaying on/fast-off kinetics distinguish ICB responders from non-responders.

From: Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice

Fig. 3: Time-dependent changes in expression of a common subset of IFN regulators displaying on/fast-off kinetics distinguish ICB responders from non-responders.

a Expression of the top 100 regulators ranked by GENIE3 importance score plotted per mouse in time by the response, genes were grouped by hierarchal clustering. b GENIE3 subnetwork of direct interactions between TFs and their target genes in AB1 and (c) in Renca, separated into responders and non-responders, depicting gene expression over time, with on/fast-off IFN genes highlighted within the boxes. d Top 10 TFs with highest GENIE3 scores between ISGs for AB1 and Renca responders (left sub-panel), with average expression for ISGs in responders (centre sub-panel) and non-responders (right sub-panel) across time points. Hive plots of direct networks for AB1 (e) and Renca (f) with TF-to-ISG edges situated in the right upper quadrant. The top 10% of (high valued) edges by GENIE3 score are highlighted in red.

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