Fig. 2: AMPK-α1/α2 deletion precipitated remodeling of the heart. | Nature Communications

Fig. 2: AMPK-α1/α2 deletion precipitated remodeling of the heart.

From: AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

Fig. 2

a Representative sub-gross images of heart slices from terminal samples stained with Hematoxylin–Eosin (left) and a higher magnification image showing the right aspect of the septal myocardium including right ventricular endocardium stained with Masson’s trichrome (right) for (i) AMPK-α1/α2 floxed (AMPK-α1/α2 FLX) and (ii) AMPK-α1/α2 knockouts (AMPK-α1/α2 KO). b Scatter plots show the (i) Fulton index [RV/(LV + S) ratio], (ii) right ventricular weight relative to body weight ratio (RV/BW), and (iii) left ventricular plus septum weight to body weight ratio (LV + S/BW) and (iv) fibrosis of the right ventricle for AMPK-α1/α2 floxed (n = 10 fields of view per mouse from n = 4 mice) and AMPK-α1/α2 KO (n = 13 fields of view per mouse from n = 3 mice). Data are expressed as mean ± SEM. Statistical significance was assessed by two-sided unpaired Student’s t test.

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