Fig. 2: Younger age is associated with a higher hub ratio in symptomatic AD. | Nature Communications

Fig. 2: Younger age is associated with a higher hub ratio in symptomatic AD.

From: Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading

Fig. 2: Younger age is associated with a higher hub ratio in symptomatic AD.

Scatterplots illustrating the association between age and the tau hub ratio for Aβ+ subjects of the A ADNI (N = 147) and B BioFINDER sample (N = 41), stratified by clinical status. C, D illustrate the association between age and the average weighted degree-based distance (i.e., shorter distance = higher connectivity) of tau epicenters (i.e., 10% of brain regions with highest tau-PET positivity which were determined on the subject level) in C ADNI and D BioFINDER. Note that the y-axis in C, D has been inverted, since lower values mean reflect higher hub-ness. β-values reflect standardized regression weights. All β- and two-sided p values were derived from linear regression controlling for sex, education (and diagnosis in symptomatic AD groups). Linear model fits (i.e., least squares line) are indicated together with 95% confidence intervals. Source data are provided as a Source Data file.

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