Fig. 4: A higher tau hub ratio facilitates tau spreading. | Nature Communications

Fig. 4: A higher tau hub ratio facilitates tau spreading.

From: Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading

Fig. 4: A higher tau hub ratio facilitates tau spreading.

A Schematic illustration of a hypothetical tau spreading model. When tau epicenters fall in a hub region with many connections to other regions, tau spread should be faster as compared to tau spread from an epicenter in a non-hub region with fewer connections. The association between age and annual tau-PET change rates for Aβ+ subjects is illustrated in B for the ADNI (N = 147) and C for the BioFINDER sample (N = 41), stratified by clinical status. Scatterplots showing the association the tau hub ratio and annual tau accumulation rates in D ADNI and E BioFINDER. β-values reflect standardized regression weights. All β-and two-sided p values were derived from linear regression controlling for sex, education (and diagnosis in symptomatic AD groups). Linear model fits (i.e., least squares line) are indicated together with 95% confidence intervals. Source data are provided as a Source Data file.

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