Fig. 5: The association between younger age and faster tau accumulation is mediated by a higher tau hub ratio. | Nature Communications

Fig. 5: The association between younger age and faster tau accumulation is mediated by a higher tau hub ratio.

From: Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading

Fig. 5: The association between younger age and faster tau accumulation is mediated by a higher tau hub ratio.

A Mediation analysis in patients with symptomatic AD (ADNI: N = 87, BioFINDER: N = 25), showing that the association between younger age and faster annual tau accumulation rates is mediated by tau hub ratio. Mediation effects (i.e., β-values, 95% confidence intervals [CI] and uncorrected two-sided p values) were determined based on bootstrapping with 10,000 iterations, while all paths were controlled for age, sex and education. B In the ADNI symptomatic AD sample with available longitudinal cognition on a memory composite (i.e., ADNI-MEM, n = 87), we plotted the association between tau-PET accumulation rates (x-axis) and cognitive change rates (y-axis). β-values reflect standardized regression weights. β-and two-sided p values were derived from linear regression, controlling for age, sex and education. Linear model fits (i.e., least squares line) are indicated together with 95% confidence intervals. Source data are provided as a Source Data file.

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