Fig. 1: Overall architecture of Uba6/Ub-AMP complexes in open and closed states. | Nature Communications

Fig. 1: Overall architecture of Uba6/Ub-AMP complexes in open and closed states.

From: Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6

Fig. 1: Overall architecture of Uba6/Ub-AMP complexes in open and closed states.The alternative text for this image may have been generated using AI.

a Schematic representation of Uba6~Ub thioester formation reaction. b Cartoon representation of crystal structure of Uba6/Ub-AMP/InsP6 in the open E1 conformation. IAD domain is in slate; AAD is in pink; FCCH is in hotpink; SCCH is in magenta; UFD is in orange; cys cap is in cyan; and Ub(a) is in gold. The catalytic cysteine is indicated by yellow sphere. AMP and InsP6 are indicated by spheres. c Cartoon representation of crystal structure of hUba6/Ub-AMP in the closed E1 conformation presented as in b. Schematic drawings of the domain organization of Uba6 with disordered regions indicated by hatched boxes are shown at the bottom of b and c.

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