Fig. 6: Results of Conditional Granger causality of intracranial field potentials in two patients.
From: Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation
a Averaged spectral Conditional Granger causality (CGC) related to anterior cingulate cortex (ACC) across 12 sessions of esTT experiment in PT511. x-axis indicates iEEG frequency in Hz and y-axis indicates magnitude of CGC. Solid lines represent CGC calculated from actual data and dotted lines represent 95% CGC values found with phase-randomized surrogate data. b Averaged CGC among 5 ROI groups. Peak CGC values at 8 Hz were shown. Colorbar represents CGC values at 8 Hz. The cells in the matrix surrounded by the red dotted lines indicates significant CGC (over 95% point from phase-randomized surrogate data distribution). c Effective connectivity (CGC) plotted on the MNI brain among ROIs. Thickness of the arrows are proportional to the CGC values of the connections (scale at right lower corner of the panel), and size of the circles represent sum of the inflow (left panel) to and outflow (right panel) from the ROIs (in-degrees and out-degrees, respectively). Location of the circles reflects actual electrode placement in the patient. d, e, f Same as (a), (b), and (c) above, but for PT384. Note PT384 had ROI coverage in OF group. Both were from medial group amygdala stimulation (See Supplementary Fig. 7 for lateral group amygdala stimulation). For the creation of brain backgrounds in panels (c) and (f), we used Conte69.32k surface mesh103 obtained from https://biomedia.doc.ic.ac.uk/brain-parcellationsurvey/) under WU-Minn HCP Consortium Open Access Data Use Terms.
