Table 2 IC50 values of inhibitory effects of ACMs on Aβ42-mediated cell damage[a] and app. KDs of ACM/Aβ42 interactions[b][c]

From: Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly

ACM

IC50 (±SD) (nM)[a]

app. KD (±SD) (nM)[b][c]

Nle3-VF

367 (±79)

14.5 (±8.0)

Nle3-LF

n.d.

11.1 (±6.0)

L3-VF

261 (±140)

38.0 (±2.0)

L3-LF

n.d.

2.6 (±1.4)

F3-VF

1032 (±297)

160.8 (±12.9)

F3-LF

262 (±115)

430.6 (±7.1)

  1. aIC50 values, means (±SD) from three independent titration assays (n = 3 technical replicates each); n.d. not determined.
  2. bDetermined by titrations of N-terminal FITC-labeled Aβ42 (5 nM; pH 7.4) with ACMs.
  3. cApp. KDs, means (±SD) from three binding curves derived from three independent assays.
Back to article page