Fig. 1: Overall structure of the E1 conformation.
From: Structural basis of ion uptake in copper-transporting P1B-type ATPases
a The structure shows the typical P-type ATPase domain setup, with three cytosolic A- (colored in yellow), P- (blue) and N- (red) domains and a membrane-spanning M-domain. The P1B-specific MA-MB helices are shown in cyan and M1-6 in grey. Functionally important features and motifs are highlighted. b Post-Albers reaction cycle. Insets demonstrate P-domain structural alignments of the determined AfCopA (E1 state) and the available LpCopA (E2P and E2.Pi; PDB-IDs 4BBJ & 4BYG) structures (in colors) to the of corresponding states of SERCA (in grey; 4H1W, 3B9B & 3FGO), with the M-domains removed for clarity. The E2 states demonstrate considerable overlap with SERCA, while the determined E1 structure displays a distinct organization.
