Fig. 3: Circular Manhattan plot for QT, JT, and QRS multi-ancestry meta-analyses. | Nature Communications

Fig. 3: Circular Manhattan plot for QT, JT, and QRS multi-ancestry meta-analyses.

From: Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

Fig. 3: Circular Manhattan plot for QT, JT, and QRS multi-ancestry meta-analyses.The alternative text for this image may have been generated using AI.

Circular Manhattan plots for QT (outer, yellow), JT (middle, red), and QRS (inner, blue) multi-ancestry GWAS linear regression meta-analyses. The Y-axis has been restricted to -log10 P-value < 30. Two-sided P-values are reported. A Bonferroni-corrected threshold (<5 × 10−8) was used to declare significance. Overlapping JT and QRS loci are labeled with the most likely candidate at the locus color coded according to a concordant (green) or discordant (purple) direction of effect at a variant level. Direction of effect was compared by comparing the lead JT variant beta with the corresponding direction of effect of the same variant in the QRS GWAS meta-analysis. This plot was produced using the R package Circlize version 0.4.10. Gu, Z. (2014) circlize implements and enhances circular visualization in R. Bioinformatics. 10.1093/bioinformatics/btu393.

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