Fig. 4: Comparison of co-localized eQTL signals for QT, JT, and QRS in right atrial appendage and left ventricle tissues. | Nature Communications

Fig. 4: Comparison of co-localized eQTL signals for QT, JT, and QRS in right atrial appendage and left ventricle tissues.

From: Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

Fig. 4: Comparison of co-localized eQTL signals for QT, JT, and QRS in right atrial appendage and left ventricle tissues.The alternative text for this image may have been generated using AI.

Colocalization analyses performed using data from GTEx (version 8), using the R package COLOC (methods). A posterior probability of >75% was used to declare significance. Boxes are color coded to show either increased (red) or decreased (blue) effect on tissue-specific gene expression. The degree of shading reflects the normalized effect sizes (and therefore no units) from the slope of the linear regression model for the effect allele relative to the non-effect allele (see methods for more information). The direction of effect has been aligned to the ECG trait prolonging allele. Y axis: Transcripts. RAA: Right atrial appendage, LV: Left ventricle.

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