Fig. 1: Schematic illustration of Trojan bacteria crossing blood–brain barrier for photothermal immunotherapy of glioblastoma. | Nature Communications

Fig. 1: Schematic illustration of Trojan bacteria crossing blood–brain barrier for photothermal immunotherapy of glioblastoma.

From: Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy

Fig. 1: Schematic illustration of Trojan bacteria crossing blood–brain barrier for photothermal immunotherapy of glioblastoma.The alternative text for this image may have been generated using AI.

a A scheme illustrating the construction of Trojan bacteria system. The nanoagents composed of silicon nanoparticle (SiNP) modified with glucose polymer (GP) (e.g, poly[4-O-(α-D-glucopyranosyl)-D-glucopyranose]) and indocyanine green (ICG) were internalized into bacterial cells (e.g., attenuated Salmonella typhimurium VNP20009 (VNP), Escherichia coli 25922 (EC)) through the bacteria-specific ATP-binding cassette (ABC) transporter to form the Trojan bacteria system (Trojan EC/VNP). b A scheme illustrating Trojan bacteria system crossing the blood–brain barrier (BBB), targeting and penetrating glioblastoma (GBM) tissues, followed by light-triggered photothermal immunotherapy of GBM in vivo. The cartoons are created by Dr. Houyu Wang.

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