Fig. 3: C–H substrate scope. | Nature Communications

Fig. 3: C–H substrate scope.

From: Stereoretentive cross-coupling of chiral amino acid chlorides and hydrocarbons through mechanistically controlled Ni/Ir photoredox catalysis

Fig. 3

Reaction conditions: 1a (0.20 mmol), oxalyl chloride (1.8 equiv), DMF (cat., 0.2 μL), and CH2Cl2 (2.0 mL). After evaporation of the remaining solvent, NiCl2·glyme (5 mol %), dtbbpy (10 mol %), 2,6-lutidine (2.0 equiv), C–H substrate (3.0 equiv), Ir[dF(CF3)ppy]2(dtbbpy)PF6 (1 mol %), and benzene (8.0 mL) were added, and the solution was irradiated for 12 h with a Penn PhD M2 photoreactor. All yields are isolated yields. ad.r. = 1:1. bd.r. = 2:1. cr.r. = 4:1; d.r. for the minor regioisomer = 1:1. d10 equiv of C–H substrate. ed.r. = 3:1.

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