Fig. 3: Comparison of EUR vs. all-ancestry (AA) analyses.
a Venn diagram of the number of significant gene-biomarker associations (p < 1.61 × 10−8, FWER ≤ 0.05) identified in either analysis (Supplementary Data 1 and 3). b Scatter plot showing the smallest p value across variant-effect- and test-types for each gene-biomarker association in the EUR-analysis (x-axis) vs. in the analysis with all ancestries (y-axis) on the negative log10-scale. The thick black box denotes the area highlighted in panel (c). Associations significant in either analysis are color-coded according to (a) and drawn thicker. The significance threshold is drawn as a light gray dashed horizontal/vertical line. Non-significant associations are drawn in gray. Associations with p > 0.1 in both analyses are not shown. d For significant gene-biomarker associations in either analysis, we show if the variant effect types and the test-types (gbvc or kernel-based) which gave the smallest p values were consistent between the two analyses.
