Fig. 7: Aging of CD8+ T cells under clinical conditions quantified by the ML algorithm.
From: Heterogeneity and transcriptome changes of human CD8+ T cells across nine decades of life
a Predicted age increase in naïve CD8+ T cells during a one-year course after diagnosis of HIV-1 infection (blood sample collection from HIV-1 infected patients and used for scRNAseq analysis39). Predicted CD8+ T cell age at diagnosis and one year later (chronological increase in age was subtracted) based on Kazer et al.39. b Predicted age increase in CAR T cells during the course of treatment (CAR T cells collection at early and very late time points during the course of treatment and used for scRNAseq analysis44). Predicted CD8+ CAR T cell age prior to infusion and in post-infusion early phase (mean 14, range 12-21 days) and late phase (mean 95, range 83-112 days) based on Sheih et al.40, N = 4. The box-whisker plots in a and b, the center line is the median, the box is from the 25th to the 75th percentile. The upper or lower whisker extends from the hinge to the 10% and 90% from the hinge for up and low, respectively. P values were calculated by two-sided T-test. The data are in Supplementary Data 7a, b.
