Fig. 5: Substrate flexibilities of PlsnB and PvcB. | Nature Communications

Fig. 5: Substrate flexibilities of PlsnB and PvcB.

From: Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate

Fig. 5

A Surface representation of 4 in the active site of PlsnB. Compound 4 is shown in the sticks. The circle indicates the region that can accommodate potential functional groups in addition to the isonitrile moiety. B Modeling of 6 in the active site of PIsnB. Interactions between the phenyl ring, the carboxylate group of 6, and the residues in the active site are well-preserved. C Superimposition of the structures of PlsnB with PvcB (PDB code: 4YLM). Key residues in the active site are shown with the numbering as in PlsnB/PvcB. D Modeling of the native substrate 4 in the active site of PvcB, assuming a similar substrate orientation is adopted as of PlsnB•Mn•4.

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