Table 2 Frailty characteristics by follow-ups and subsets

From: Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults

 

N (participants)

Frailty index (means ± SD)

Frailty categories a (N/%)

Non-frail

Pre-frail

Frail

Subset I (ESTHER study)

Baseline

998

0.139 ± 0.092

413 (41.4)

458 (45.9)

127 (12.7)

2-year follow-up

966

0.152 ± 0.099

347 (35.9)

446 (46.2)

173 (17.9)

5-year follow-up

843

0.171 ± 0.107

253 (30.0)

387 (45.9)

203 (24.1)

8-year follow-up

726

0.198 ± 0.109

151 (20.8)

349 (48.1)

226 (31.1)

11-year follow-up

497

0.211 ± 0.117

93 (18.7)

230 (46.3)

174 (35.0)

Subset II (ESTHER study)

Baseline

730

0.143 ± 0.092

282 (38.6)

339 (46.4)

109 (14.9)

2-year follow-up

693

0.152 ± 0.099

255 (36.8)

328 (47.3)

110 (15.9)

5-year follow-up

618

0.164 ± 0.105

201 (32.5)

278 (45.0)

139 (22.5)

8-year follow-up

517

0.190 ± 0.108

117 (22.6)

248 (48.0)

152 (29.4)

11-year follow-up

385

0.199 ± 0.117

91 (23.6)

164 (42.6)

130 (33.8)

Subset III (ESTHER study)

Baseline

538

0.146 ± 0.096

206 (38.3)

250 (46.5)

82 (15.2)

2-year follow-up

507

0.157 ± 0.106

188 (37.1)

212 (41.8)

107 (21.1)

5-year follow-up

449

0.169 ± 0.110

149 (33.2)

189 (42.1)

111 (24.7)

8-year follow-up

369

0.197 ± 0.118

94 (25.5)

151 (40.9)

124 (33.6)

11-year follow-up

258

0.200 ± 0.125

64 (24.8)

102 (39.5)

92 (35.7)

Subset IV (KORA-Age study)

Baseline

1025

0.184 ± 0.120

236 (23.0)

574 (56.0)

215 (21.0)

4-year follow-up

782

0.217 ± 0.133

130 (16.6)

401 (51.3)

251 (32.1)

8-year follow-up

593

0.241 ± 0.158

93 (15.7)

282 (47.6)

218 (36.8)

  1. SD standard deviation.
  2. aNon-frail: 0 < frailty index ≤ 0.100; pre-frail: 0.100 < frailty index < 0.250; frail: 0.250 ≤ frailty index.
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