Fig. 6: Total synthesis of 4-epi-phyllanthine (4) via hydrogen atom transfer (HAT)-based C2-epimerization of the neosecurinine scaffold. | Nature Communications

Fig. 6: Total synthesis of 4-epi-phyllanthine (4) via hydrogen atom transfer (HAT)-based C2-epimerization of the neosecurinine scaffold.

From: Collective total synthesis of C4-oxygenated securinine-type alkaloids via stereocontrolled diversifications on the piperidine core

Fig. 6: Total synthesis of 4-epi-phyllanthine (4) via hydrogen atom transfer (HAT)-based C2-epimerization of the neosecurinine scaffold.The alternative text for this image may have been generated using AI.

a Ellman’s light-mediated piperidine epimerization (ref. 41); b Light-mediated C2-epimerization of 30 enables the synthesis of 4-epi-phyllanthine (4). ET electron transfer, HAT hydrogen atom transfer.

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