Fig. 7: Network analysis of the major molecular landscape in hepatic reprogramming. | Nature Communications

Fig. 7: Network analysis of the major molecular landscape in hepatic reprogramming.

From: PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest

Fig. 7

a An integrative TPCW based on the findings of this study and existing knowledge illustrates the regulatory relationships among FHH, 24 FHH-regulated TFs, two screened central PKs, and 60 curated genes related to hepatic lineage, ferroptosis, and cell cycle progression. b PIM1-centered subnetwork during hepatic lineage reprogramming. c Working model showing potential roles of PIM1 in hepatic lineage reprogramming.

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