Fig. 1: Manhattan plot and quantile-quantile plot from the myelofibrosis genome-wide association study.
From: Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis
The association -log10 P-values are plotted for each tested genetic variant on the y-axis (two-sided, logistic regression) and chromosomal position on the x-axis. The nearest gene for each identified locus is labeled. The red line indicates the genome-wide significance threshold (5 × 10−8). The quantile–quantile plot displays observed versus expected −log10 P-values. Source data are provided as a Source Data file.
