Table 1 Mendelian randomization results using variants and summary statistics from Li et al.a

From: Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis

Method

OR (95% CI)

p-valueb

Maximum-likelihood

8.04 (3.41, 18.93)

1.88 × 10−6

Simple median

6.25 (2.04, 19.10)

1.32 × 10−3

Weighted median

5.07 (1.75, 14.70)

2.76 × 10−3

IVWc

7.69 (3.29, 17.97)

2.43 × 10−6

MR-Egger

13.49 (1.07, 169.93)

4.41 × 10−2

Intercept

0.97 (0.85, 1.11)

0.6475

  1. aFive variants (rs4691895, rs7705526, rs34991172, rs228595, rs34978822) were detected to have evidence of pleiotropy (FDR < 0.2) as detailed in Supplemental Table 11 and removed from the MR analyses.
  2. bAll reported tests are two-sided.
  3. cInverse-variance weighted.
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