Fig. 7: Species specificity of Cp40 for human and non-human primate complement. | Nature Communications

Fig. 7: Species specificity of Cp40 for human and non-human primate complement.

From: Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors

Fig. 7

a Complement-inhibitory activity of Cp40 in human, pig, dog, rabbit, rat, and mouse plasma as assessed by classical pathway ELISA. Negative values have been defined a zero inhibition. Raw data and calculated values are available in the source data file. b Comparison of Cp40 binding to human C3b (based on crystal structure, shown as transparent and light blue surface) and mouse C3b (homology model, shown as grew surface). Labels correspond to human C3. c Close-up view on (1Me)Trp5 and its interaction to C3b. In the case of mouse C3b, relevant interactions to His392 are missing. d Pairwise sequence alignment (EMBOSS Needle) of human and mouse C3 within the MG4/MG5 domain region. Identical, strongly similar, and weakly similar residues are highlighted in blue, orange, and red, respectively. C3 residues engaging in intermolecular interactions with Cp40 are marked with arrows.

Back to article page