Table 2 Generic Biomolecular Model Parameters
From: Layered feedback control overcomes performance trade-off in synthetic biomolecular networks
Parameters | Description | Unit | Estimates |
|---|---|---|---|
βA | max transcription rate of the inducible promoter Px | fM/min | 2 |
Kx | activation coefficient of the chemical inducer x | nM | 1.4e4 |
KR | repression coefficient of the sRNA repressor | fM | 20 |
Kp | repression coefficient of the protein repressor | fM | 200 |
dm | degradation/dilution rate of mRNA | 1/min | 0.1 |
ktp | translation rate of the inducing protein Pind | 1/min | 0.1 |
d | degradation/dilution rate of proteins, dominated by dilution | 1/min | 0.03 |
Kr | the maturation rate of the activating complex | 1/min | 0.1 |
βB | max transcription rate of the Cind inducible promoter | fM/min | 20 |
Kind | activation coefficient of Cind | nM | 200 |
dr | degradation/dilution rate of sRNA | 1/min | 0.3 |
α | maturation rate of GOI | 1/min | 0.2 |
x | the chemical inducer that activates Px | nM | 2.0e6 |
ktg | translation rate of GOI | 1/min | 0.1 |
ftx | scaling factor of universal transcription | NA | 1 |
ftl | scaling factor of universal translation | NA | 1 |
ktr | translation rate of the regulator protein | 1/min | 0.04 |
dpr | degradation/dilution rate of regulator proteins, dominated by dilution | 1/min | 0.03 |
