Fig. 4: Binding kinetics depend on the number of previously bound units.
From: A multi-state dynamic process confers mechano-adaptation to a biological nanomachine
The binding rate kon for an individual stator unit at different numbers of bound stator units (N). The black curve was obtained from the simple model kon(N) = kon(0)f1(N)f2(N), where kon(0) = 0.0037 s−1 is the on rate for N = 0 and the two functions, f1 and f2, are given by \({f}_{1}(N)=(1+A(1-\exp \left[-BN\right]))\) and \({f}_{2}(N)=1-\exp \left[-C/N\right]\). The parameters A, B, and C are determined from fitting the experimental data: A = 0.23, B = 1.8, C = 3.8. The data presented are means and the error bars represent standard deviation. The sample size for 0, 1, 2,... 8 stator units is 74, 63, 75, 70, 77, 81, 80, 83, and 74, respectively.
