Table 1
Childhood Onset Asthma | Adult Onset Asthma | Nasal Specific? | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | Gene | Position (Hg38) | HSQ | TWAS.Z | TWAS.P | PP3 | PP4 | TWAS.Z | TWAS.P | PP3 | PP4 | |
Childhood Onset Asthma | ||||||||||||
1 | LOC115110 | 1:2549920–2557011 | 0.46 | 4.63 | 3.73E−06 | 0.02 | 0.98 | 3.15 | 1.65E−03 | NA | NA | Y |
2 | RIIAD1 | 1:151721537–151729606 | 0.54 | −5.99 | 2.09E−09 | 1.00 | 0.00 | −1.87 | 6.12E−02 | NA | NA | Y |
3 | MRPL9 | 1:151759643–151763916 | 0.14 | −5.96 | 2.45E−09 | 1.00 | 0.00 | −1.70 | 8.82E−02 | NA | NA | Y |
4 | LINGO4 | 1:151800265–151805442 | 0.42 | 7.21 | 5.39E−13 | 1.00 | 0.00 | 0.88 | 3.77E−01 | NA | NA | N |
5 | FLG-AS1 | 1:152313459–152366692 | 0.31 | −7.00 | 2.60E−12 | 1.00 | 0.00 | −1.52 | 1.29E−01 | NA | NA | N |
6 | FCER1G | 1:161215297–161219248 | 0.19 | 6.40 | 1.57E−10 | 0.00 | 1.00 | 3.70 | 2.12E−04 | NA | NA | N |
7 | IL1R2 | 2:101991844–102028422 | 0.07 | −6.27 | 3.57E−10 | 0.99 | 0.00 | −3.81 | 1.41E−04 | NA | NA | Y |
8 | SLC9A4 | 2:102473303–102533972 | 0.21 | −7.50 | 6.55E−14 | 1.00 | 0.00 | −4.38 | 1.18E−05 | NA | NA | Y |
9 | RFTN2 | 2:197570803–197675860 | 0.31 | −4.77 | 1.86E−06 | 0.07 | 0.93 | −4.06 | 4.87E−05 | NA | NA | N |
10 | NEU4 | 2:241809065–241817413 | 0.49 | 6.67 | 2.51E−11 | 1.00 | 0.00 | 2.92 | 3.55E−03 | NA | NA | Y |
11 | CCDC66 | 3:56557156–56621820 | 0.50 | −4.69 | 2.75E−06 | 0.08 | 0.92 | −3.12 | 1.82E−03 | NA | NA | Y |
12 | EAF2 | 3:121835187–121886526 | 0.10 | −5.16 | 2.48E−07 | 0.50 | 0.50 | −2.73 | 6.41E−03 | NA | NA | N |
13 | SLC15A2 | 3:121894324–121944187 | 0.46 | 5.61 | 2.02E−08 | 0.15 | 0.85 | 2.89 | 3.80E−03 | NA | NA | Y |
14 | RUVBL1 | 3:128080957–128123828 | 0.29 | −5.18 | 2.22E−07 | 0.97 | 0.03 | −2.28 | 2.26E−02 | NA | NA | Y |
15 | TIPARP | 3:156674416–156706768 | 0.08 | 5.08 | 3.72E−07 | 0.15 | 0.84 | 2.56 | 1.05E−02 | NA | NA | Y |
16 | FAM114A1 | 4:38867733–38945744 | 0.13 | −5.58 | 2.34E−08 | 0.37 | 0.06 | 1.39 | 1.64E−01 | NA | NA | N |
17 | NFKB1 | 4:102501329–102617302 | 0.40 | −4.93 | 8.35E−07 | 0.21 | 0.79 | −1.37 | 1.71E−01 | NA | NA | Y |
18 | IL7R | 5:35856875–35879603 | 0.07 | −4.95 | 7.49E−07 | 0.17 | 0.69 | −2.81 | 4.99E−03 | NA | NA | Y |
19 | LOC553103 | 5:132311276–132369916 | 0.43 | −4.76 | 1.91E−06 | 1.00 | 0.00 | −3.61 | 3.12E−04 | NA | NA | Y |
20 | SLC22A5 | 5:132369709–132395614 | 0.37 | 5.03 | 4.86E−07 | 1.00 | 0.00 | 3.16 | 1.60E−03 | NA | NA | N |
21 | SEPT8 | 5:132750817–132777869 | 0.12 | 6.24 | 4.43E−10 | 1.00 | 0.00 | 4.11 | 3.90E−05 | NA | NA | N |
22 | RGS14 | 5:177357843–177372598 | 0.50 | −4.89 | 1.02E−06 | 0.26 | 0.73 | −2.96 | 3.05E−03 | NA | NA | N |
23 | ITGB8 | 7:20331102–20415759 | 0.08 | −5.73 | 1.02E−08 | 0.64 | 0.29 | −3.81 | 1.40E−04 | NA | NA | Y |
24 | JAZF1 | 7:27830574–28180818 | 0.19 | 4.89 | 1.02E−06 | 1.00 | 0.00 | 2.92 | 3.45E−03 | NA | NA | Y |
25 | ERMP1 | 9:5784572–5833081 | 0.38 | 5.80 | 6.67E−09 | 1.00 | 0.00 | 4.23 | 2.35E−05 | NA | NA | Y |
26 | HHEX | 10:92689924–92695651 | 0.25 | 6.98 | 2.90E−12 | 0.02 | 0.98 | 4.60 | 4.19E−06 | NA | NA | Y |
27 | WBP1L | 10:102743970–102816264 | 0.40 | 4.80 | 1.55E−06 | 1.00 | 0.00 | 0.96 | 3.37E−01 | NA | NA | Y |
28 | SYT13 | 11:45240302–45286333 | 0.45 | −4.86 | 1.15E−06 | 0.03 | 0.97 | −2.88 | 3.99E−03 | NA | NA | Y |
29 | MYO7A | 11:77128264–77215241 | 0.12 | 5.18 | 2.21E−07 | 0.99 | 0.00 | 3.08 | 2.09E−03 | NA | NA | Y |
30 | AAMDC | 11:77821162–77872352 | 0.05 | −5.00 | 5.83E−07 | 0.26 | 0.56 | −1.06 | 2.87E−01 | NA | NA | Y |
31 | RPS26 | 12:56041902–56044223 | 0.33 | 6.87 | 6.58E−12 | 1.00 | 0.00 | 4.59 | 4.54E−06 | NA | NA | N |
32 | NABP2 | 12:56224341–56229854 | 0.07 | −5.99 | 2.06E−09 | 0.63 | 0.03 | −4.45 | 8.69E−06 | NA | NA | Y |
33 | SPPL3 | 12:120762510–120904352 | 0.19 | 7.54 | 4.86E−14 | 0.97 | 0.03 | 2.79 | 5.27E−03 | NA | NA | N |
34 | ABCB9 | 12:122920951–122966509 | 0.14 | −4.74 | 2.18E−06 | 0.96 | 0.05 | −0.76 | 4.45E−01 | NA | NA | N |
35 | CDK2AP1 | 12:123260970–123272316 | 0.44 | 5.26 | 1.41E−07 | 0.48 | 0.52 | 0.86 | 3.87E−01 | NA | NA | N |
36 | BAHD1 | 15:40439721–40468242 | 0.05 | 4.74 | 2.19E−06 | 0.62 | 0.08 | 0.83 | 4.07E−01 | NA | NA | Y |
37 | CHP1 | 15:41231239–41281885 | 0.33 | −6.04 | 1.53E−09 | 0.79 | 0.21 | −2.73 | 6.26E−03 | NA | NA | N |
38 | OIP5-AS1 | 15:41284003–41299597 | 0.19 | −4.69 | 2.70E−06 | 0.87 | 0.13 | −1.35 | 1.78E−01 | NA | NA | N |
39 | ITPKA | 15:41493858–41503559 | 0.21 | 5.36 | 8.54E−08 | 0.01 | 0.99 | 2.83 | 4.72E−03 | NA | NA | Y |
40 | IQGAP1 | 15:90388241–90502243 | 0.41 | −5.27 | 1.34E−07 | 0.01 | 0.99 | −1.10 | 2.72E−01 | NA | NA | N |
41 | DEXI | 16:10928891–10942400 | 0.32 | −7.41 | 1.23E−13 | 1.00 | 0.00 | −2.91 | 3.66E−03 | NA | NA | Y |
42 | NSMCE1 | 16:27224994–27268792 | 0.26 | 7.19 | 6.65E−13 | 1.00 | 0.00 | 3.11 | 1.84E−03 | NA | NA | Y |
43 | IL4R | 16:27313909–27364778 | 0.17 | 5.36 | 8.17E−08 | 0.66 | 0.33 | 2.59 | 9.49E−03 | NA | NA | N |
44 | ATP2A1 | 16:28878488–28904509 | 0.08 | −4.62 | 3.80E−06 | 0.30 | 0.66 | –0.97 | 3.33E−01 | NA | NA | Y |
45 | LINC00672 | 17:38925168–38929384 | 0.10 | 6.78 | 1.19E−11 | 0.63 | 0.01 | −1.31 | 1.89E−01 | NA | NA | Y |
46 | MED1 | 17:39404285–39451274 | 0.17 | 8.20 | 2.46E−16 | 1.00 | 0.00 | −0.11 | 9.16E−01 | NA | NA | Y |
47 | STARD3 | 17:39637080–39664201 | 0.35 | 14.75 | 3.30E–49 | 1.00 | 0.00 | 2.05 | 4.07E−02 | NA | NA | N |
48 | PGAP3 | 17:39671122–39688070 | 0.61 | 15.28 | 9.73E–53 | 1.00 | 0.00 | 1.54 | 1.24E−01 | NA | NA | N |
49 | ERBB2 | 17:39688084–39728662 | 0.32 | 13.38 | 7.45E–41 | 1.00 | 0.00 | 0.48 | 6.33E−01 | NA | NA | N |
50 | GRB7 | 17:39737909–39747285 | 0.09 | 10.14 | 3.85E–24 | 0.99 | 0.00 | −2.49 | 1.29E−02 | NA | NA | Y |
51 | IKZF3 | 17:39757715–39864188 | 0.11 | −18.26 | 1.70E–74 | 0.42 | 0.58 | −4.54 | 5.66E−06 | NA | NA | Y |
52 | GSDMB | 17:39904595–39918650 | 0.52 | 23.68 | 5.47E−124 | 0.01 | 0.99 | 2.71 | 6.70E−03 | NA | NA | N |
53 | GSDMA | 17:39962973–39977766 | 0.34 | −13.40 | 5.74E–41 | 1.00 | 0.00 | −2.93 | 3.43E−03 | NA | NA | N |
54 | PSMD3 | 17:39980768–39997960 | 0.06 | 11.33 | 9.54E–30 | 1.00 | 0.00 | 2.18 | 2.95E−02 | NA | NA | Y |
55 | MED24 | 17:40019097–40054636 | 0.45 | 5.46 | 4.73E−08 | 1.00 | 0.00 | 0.02 | 9.85E−01 | NA | NA | N |
56 | RARA-AS1 | 17:40340867–40343136 | 0.06 | 5.84 | 5.11E−09 | 0.98 | 0.01 | 1.63 | 1.04E−01 | NA | NA | Y |
57 | STAT5A | 17:42287547–42311942 | 0.13 | −4.69 | 2.76E−06 | 0.72 | 0.28 | −3.43 | 5.95E−04 | NA | NA | Y |
58 | HEXIM1 | 17:45147317–45152101 | 0.27 | −6.01 | 1.80E−09 | 1.00 | 0.00 | −1.24 | 2.14E−01 | NA | NA | Y |
59 | SPATA32 | 17:45254393–45262112 | 0.73 | −5.21 | 1.88E−07 | 0.98 | 0.02 | −2.71 | 6.67E−03 | NA | NA | N |
60 | LRRC37A4P | 17:45505883–45520523 | 0.32 | 5.66 | 1.55E−08 | 1.00 | 0.00 | 0.17 | 8.64E−01 | NA | NA | N |
61 | LOC644172 | 17:45600103–45601862 | 0.10 | −5.71 | 1.16E−08 | 1.00 | 0.00 | −0.46 | 6.44E−01 | NA | NA | Y |
62 | MGC57346 | 17:45620329–45637963 | 0.22 | −5.52 | 3.34E−08 | 1.00 | 0.00 | −0.39 | 6.97E−01 | NA | NA | Y |
63 | CRHR1-IT1 | 17:45638975–45646229 | 0.26 | −5.63 | 1.82E−08 | 1.00 | 0.00 | −0.42 | 6.78E−01 | NA | NA | N |
64 | MAPT | 17:45894382–46028333 | 0.11 | 4.84 | 1.32E−06 | 1.00 | 0.00 | −0.09 | 9.29E−01 | NA | NA | N |
65 | KANSL1 | 17:46029916–46225374 | 0.14 | −5.19 | 2.06E−07 | 1.00 | 0.00 | −0.18 | 8.55E−01 | NA | NA | N |
66 | KANSL1-AS1 | 17:46193573–46196723 | 0.29 | −5.22 | 1.75E−07 | 1.00 | 0.00 | −0.07 | 9.47E−01 | NA | NA | N |
67 | LRRC37A | 17:46295131–46337794 | 0.40 | −6.01 | 1.85E−09 | 1.00 | 0.01 | −0.16 | 8.72E−01 | NA | NA | N |
68 | ZNF652 | 17:49289206–49362473 | 0.46 | −5.72 | 1.07E−08 | 0.97 | 0.03 | −3.31 | 9.29E−04 | NA | NA | Y |
69 | SPOP | 17:49598884–49678163 | 0.08 | 5.03 | 4.87E−07 | 0.60 | 0.02 | 4.09 | 4.25E−05 | NA | NA | Y |
70 | SMAD4 | 18:51030213–51085041 | 0.25 | −6.63 | 3.43E−11 | 0.06 | 0.94 | −2.50 | 1.25E−02 | NA | NA | N |
71 | POLI | 18:54269479–54298234 | 0.52 | 6.28 | 3.49E−10 | 0.41 | 0.60 | 3.07 | 2.17E−03 | NA | NA | N |
72 | MUC16 | 19:8848844–8981342 | 0.25 | −6.66 | 2.69E−11 | 0.05 | 0.96 | −2.77 | 5.53E−03 | NA | NA | Y |
73 | FOXA3 | 19:45864260–45873797 | 0.42 | 5.12 | 3.13E−07 | 0.03 | 0.97 | 4.24 | 2.22E−05 | NA | NA | Y |
74 | STMN3 | 20:63639705––63653610 | 0.23 | −5.23 | 1.65E−07 | 0.03 | 0.97 | −3.36 | 7.75E−04 | NA | NA | N |
75 | LIME1 | 20:63735701–63739107 | 0.18 | 4.74 | 2.14E−06 | 0.72 | 0.28 | 3.00 | 2.66E−03 | NA | NA | Y |
76 | RANGAP1 | 22:41244777–41286251 | 0.21 | 5.20 | 2.00E−07 | 0.58 | 0.42 | 2.59 | 9.63E−03 | NA | NA | N |
77 | TOB2 | 22:41433488–41447023 | 0.05 | −6.02 | 1.74E−09 | 0.05 | 0.95 | −3.87 | 1.09E−04 | NA | NA | Y |
78 | PHF5A | 22:41459717–41468704 | 0.05 | 5.92 | 3.22E−09 | 0.27 | 0.73 | 4.15 | 3.34E−05 | NA | NA | Y |
79 | XRCC6 | 22:41621163–41664048 | 0.04 | −5.03 | 4.80E−07 | 0.34 | 0.59 | −2.83 | 4.60E−03 | NA | NA | N |
80 | C22orf46 | 22:41690543–41698136 | 0.13 | −4.78 | 1.76E−06 | 0.84 | 0.16 | −2.65 | 7.96E−03 | NA | NA | Y |
81 | MEI1 | 22:41699514–41799455 | 0.16 | 4.66 | 3.20E−06 | 0.86 | 0.14 | 2.80 | 5.19E−03 | NA | NA | N |
Shared | ||||||||||||
82 | IL18R1 | 2:102356283–102398775 | 0.08 | −9.16 | 5.05E–20 | 0.54 | 0.05 | −5.31 | 1.11E−07 | 0.56 | 0.02 | N |
83 | D2HGDH | 2:241734579–241768816 | 0.64 | 10.31 | 6.63E–25 | 1.00 | 0.00 | 6.61 | 3.85E−11 | 1.00 | 0.00 | N |
84 | GAL3ST2 | 2:241776825–241804287 | 0.43 | 8.87 | 7.02E−19 | 1.00 | 0.00 | 6.83 | 8.41E−12 | 1.00 | 0.00 | Y |
85 | TSLP | 5:111070080–111078024 | 0.34 | 14.68 | 8.88E–49 | 1.00 | 0.00 | 10.29 | 7.77E–25 | 1.00 | 0.00 | N |
86 | PDLIM4 | 5:132257658–132273454 | 0.17 | 7.17 | 7.77E−13 | 1.00 | 0.00 | 7.97 | 1.64E−15 | 0.99 | 0.01 | N |
87 | MIR3936 | 5:132365490–132365599 | 0.09 | −5.74 | 9.74E−09 | 1.00 | 0.00 | −4.98 | 6.52E−07 | 1.00 | 0.00 | Y |
88 | RAD50 | 5:132556924–132644621 | 0.12 | −8.41 | 4.00E−17 | 0.83 | 0.02 | −7.74 | 9.91E−15 | 0.10 | 0.89 | N |
89 | BACH2 | 6:89926528–90296908 | 0.09 | 5.73 | 1.01E−08 | 0.14 | 0.84 | 5.15 | 2.61E−07 | 0.14 | 0.84 | Y |
90 | IL33 | 9:6215786–6257983 | 0.25 | 18.84 | 3.67E–79 | 0.00 | 1.00 | 12.41 | 2.18E–35 | 0.01 | 0.99 | Y |
91 | RAB5B | 12:55973913–55996683 | 0.05 | 6.23 | 4.57E−10 | 0.42 | 0.15 | 6.25 | 4.22E−10 | 0.07 | 0.86 | Y |
92 | UBAC2-AS1 | 13:99196374–99200757 | 0.09 | 5.96 | 2.56E−09 | 0.14 | 0.86 | 5.51 | 3.62E−08 | 0.28 | 0.72 | Y |
93 | UBAC2 | 13:99200425–99386499 | 0.29 | −6.60 | 4.20E−11 | 0.04 | 0.96 | −4.98 | 6.32E−07 | 0.20 | 0.80 | Y |
Adult Onset Asthma | ||||||||||||
94 | RERE | 1:8352404–8817640 | 0.14 | 4.30 | 1.71E−05 | NA | NA | 4.91 | 8.90E−07 | 0.02 | 0.98 | N |
95 | ZDHHC18 | 1:26826710–26855720 | 0.07 | 1.27 | 2.04E−01 | NA | NA | 4.62 | 3.85E−06 | 0.09 | 0.86 | N |
96 | LOC100130476 | 6:137823670–137868233 | 0.08 | 2.60 | 9.38E−03 | NA | NA | 4.67 | 3.07E−06 | 0.29 | 0.70 | Y |
97 | C7orf26 | 7:6590021–6608726 | 0.06 | 2.03 | 4.20E−02 | NA | NA | 4.96 | 7.05E−07 | 0.23 | 0.47 | Y |
98 | MUC2 | 11:1074875–1110508 | 0.21 | −2.10 | 3.56E−02 | NA | NA | −5.24 | 1.65E−07 | 0.02 | 0.98 | Y |
99 | MUC5AC | 11:1157953–1201141 | 0.32 | 2.74 | 6.21E−03 | NA | NA | 7.22 | 5.13E−13 | 0.02 | 0.98 | Y |
100 | FADS1 | 11:61799625–61817057 | 0.32 | 1.62 | 1.05E−01 | NA | NA | 6.49 | 8.49E−11 | 0.04 | 0.96 | Y |
101 | SIK2 | 11:111602391–111726917 | 0.27 | −2.63 | 8.44E−03 | NA | NA | −5.06 | 4.10E−07 | 0.21 | 0.79 | N |
102 | HDAC7 | 12:47782711–47819980 | 0.16 | −0.98 | 3.29E−01 | NA | NA | −4.62 | 3.92E−06 | 0.39 | 0.60 | Y |
