Fig. 5: Enhancement of therapeutic effects of IgETRAP by B. longum in a food allergy model causing acute diarrhea.
a Experimental schedule for an OVA-induced food allergy model and administrations of IgETRAP and B. longum. B. longum was mixed with powdered mouse food, which was offered on an ad-libitum basis to mice. i.p., intraperitoneal; i.g., intragastric. b Effect of IgETRAP and B. longum alone and in combination on allergy-induced diarrhea. c, d Serum levels of free and total IgE (c), and MCPT-1 (d). The combined data of three independent experiments is shown (n = 16 mice in groups of OVA (Red circle), OVA + IgETRAP + B. longum (Blue square) and PBS (Black circle); 15 mice in OVA + B. longum group (Green triangle); 18 mice in OVA + IgETRAP group (Purple triangle)). Statistical analyses were performed by Kaplan–Meier survival curve analysis with log-rank (Mantel-Cox) test to OVA group (b) and unpaired two-tailed Student’s t-test (c, d). Data are presented as means values ± SEM. Specific p-values are indicated in the figure. Source data are provided as a Source Data file.
