Fig. 1: DNA methylation signatures in retinoblastoma (RB).
From: Characterizing DNA methylation signatures of retinoblastoma using aqueous humor liquid biopsy
A Unsupervised hierarchical clustering of the differentially methylated probes between RB and retina samples. The top annotation indicates sample type. Green and blue bars indicate the retina (green, n = 12) and RB samples (RB_SR, n = 30), respectively, from dataset GSE57362. Orange bars highlight the four primary RB tumor samples collected for this study (RB_CHLA, n = 4). B MDS plot showing that RB samples (n = 34) can be distinguished from retina (n = 12) using the panel of differentially methylated probes in A. C Genomic location of the hyper- and hypo- CpGs on promoter (TSS, 5’UTR, and 1st exon), gene body, other and enhancer. Total means the probe distribution on EPIC array. Source data are provided as a Source Data file.
