Fig. 4: Cell viability and in vivo evaluations in rabbit eyes.
From: Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care
a Cell viability assay of HCEpiCs seeded on the SSCL without (blue bars) and with (green bars) the presence of the PDA adhesive as compared to the bare soft contact lens (red bars) (n = 4). b Quantified accumulation of proteins on the bare soft contact lens (red bar) and the SSCL (blue bar) before (left column, p = 0.02194 before disinfecting the bare soft contact lens vs. the ocular tonometer, n = 5; p = 0.00115 before vs. after disinfecting the bare soft contact lens, n = 5) and after (right column, p = 0.00979 before vs. after disinfecting the ocular tonometer, n = 5) disinfection. Significance was set at ***p < 0.01, and **p < 0.1. c Representative surface fluorescence image of the bare soft contact lens (top row) and the SSCL (bottom row) before (left column) and after (right column) disinfection. d Photographs of the rabbit eye wearing the SSCL (left panel) and the bare soft contact lens (right panel). e Representative AS-OCT image of the rabbit eye after 1 h of wearing the SSCL. f Representative photomicrographs of the rabbit eye with H&E staining displaying epithelial erosion and mild mixed inflammation with edema at the limbus after 24-h wear of the SSCL (left panel) and the bare soft contact lens (right panel). g Representative photomicrographs of the rabbit eye with H&E staining displaying no abnormality at the limbus after 2-week wear of the SSCL (left panel) as compared to those of the naked eye (right panel).
